兔抗ABCA4多克隆抗体

产品编号：D161218 品牌：BBI

产品特点：

技术规格

Background:	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.
Applications:	ELISA, IHC
Name of antibody:	ABCA4
Immunogen:	Synthetic peptide of human ABCA4
Full name:	ATP-binding cassette, sub-family A (ABC1), member 4
Synonyms：	FFM; RMP; ABCR; RP19; STGD; ABC10; ARMD2; CORD3; STGD1
SwissProt:	P78363
ELISA Recommended dilution:	2000-5000
IHC positive control:	Human colon cancer and Human thyroid cancer
IHC Recommend dilution:	25-100