| 溶解性 | DMSO 79 mg/mL Water <1 mg/mL Ethanol 1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | A66 is a potent and specific p110α inhibitor with IC50 of 32 nM, >100 fold selectivity for p110α over other class-I PI3K isoforms. |
| 生化机理 | A66 is a highly specific and selective p110α inhibitor with IC50 of 32,30 and 43 nM for p110α, p110α/E545K, p110α/H1047R, respectively. A66 S potently blocks phosphorylation of Akt/PKB in a subgroup of the cell lines tested demonstrates that some cell types are highly dependent on p110α activity. A66 is more than 100 fold less active against the other class-I PI 3-kinase isoforms and had not inhibitory activity against 200 protein kinases when tested at 10 micromolar. This makes it the most selective and specific p110alpha inhibitor available for research purposes. A66 S is more efficacious at inducing growth delay in HCT116. While A66 S did not induce tumor regression in xenograft models the ability to induce growth delay indicates p110α selective have to ability to be effective as cytostatic agents in some tumor types. |
| 别名 | (2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide;(2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide |
A66,PI 3-激酶p110α抑制剂
A66 （订货以英文为准）
编号：A128051
CAS号：1166227-08-2
分子式：C17H23N5O2S2
分子量：393.53
| 产品名称 | A66 |
| 中文名称 | A66,PI 3-激酶p110α抑制剂 |
| CAS号 | 1166227-08-2 |
| MDL编码 | MFCD22378485 |
| 分子式（M.F.） | C17H23N5O2S2 |
| 分子量（M.W.） | 393.53 |
| 储存条件 | -20°C储存 |
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