| 溶解性 | DMSO ≥42mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Alisertib (MLN8237)是Aurora A选择性抑制剂，IC50为1.2 nM，比对Aurora B的抑制性高200倍。 |
| 备注 | Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3. |
| 生化机理 | Alisertib is a selective Aurora kinase A inhibitor with a median IC50 of 61 nM. Alisertib is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the Aurora A kinase (serine/threonine protein kinase) with potential antineoplastic activity. |
| 别名 | MLN 8237; MLN8237；MLN-8237;4-((9-氯-7-(2-氟-6-甲氧基苯基)-5H-嘧啶并(5,4-d)(2)苯并氮杂卓-2-基)氨基)-2-甲氧基苯甲酸;;MLN 8237; MLN8237；MLN-8237; 4-((9-chloro-7-(2-fluoro-6-methoxyphenyl)-5h-pyrimido(5,4-d)(2)benzazepin-2-yl)amino)-2-methoxybenzoic acid; |
Alisertib (MLN8237)
Alisertib (MLN8237) （订货以英文为准）
编号：A126379
CAS号：1028486-01-2
分子式：C27H20CLFN4O4
分子量：518.94
| 产品名称 | Alisertib (MLN8237) |
| 中文名称 | Alisertib (MLN8237) |
| CAS号 | 1028486-01-2 |
| 分子式（M.F.） | C27H20CLFN4O4 |
| 分子量（M.W.） | 518.94 |
| 储存条件 | -20°C储存 |
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