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GW842166X,cannabinoid receptor CB2受体激动剂

GW842166X （订货以英文为准）

编号：G129840
CAS号：666260-75-9
分子式：C18H17CL2F3N4O2
分子量：449.25
货号 品牌 包装 目录价 您的价格 库存 数量 购买
G129840-5mg 阿拉丁 5mg ¥580.90
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G129840-25mg 阿拉丁 25mg ¥2059.90
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G129840-100mg 阿拉丁 100mg ¥5190.90
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产品名称 GW842166X
中文名称 GW842166X,cannabinoid receptor CB2受体激动剂
CAS号 666260-75-9
分子式（M.F.） C18H17CL2F3N4O2
分子量（M.W.） 449.25
储存条件 -20°C储存
溶解性DMSO 20 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
应用An agonist of the CB2 receptor
产品介绍GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor.
备注GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase 2.
生化机理GW842166X has an oral bioavailability of 58% and a half-life of 3 h when dosed orally in the rat. GW842166X has extremely high potency with an oral ED50 of 0.1 mg/kg and shows full reversal of hyperalgesia at 0.3 mg/kg in the FCAa model of inflammatory pain. GW842166X orally administrated at a dose of 15 mg/kg for 8 days produced a significant reversal of the CCI induced decrease in paw withdrawal threshold in a rat model of neuropathic pain.
别名GW 842166；2-(2,4-二氯苯基氨基)-4-三氟甲基嘧啶-5-羧酸[(四氢吡喃-4-基)甲基]酰胺;GW 842166;2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid [(tetrahydropyran-4-yl)methyl]amide
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