概述
Fusion protein corresponding to a region derived from 32-317 amino acids of human GRIK2
技术规格
| Full name: | glutamate ionotropic receptor kainate type subunit 2 |
| Synonyms: | EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2 |
| Swissprot: | Q13002 |
| Gene Accession: | BC037954 |
| Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | Escherichia coli |
| Tags: | His tag C-Terminus, GST tag N-Terminus |
| Background: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. |
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