概述
Fusion protein corresponding to a region derived from 345-562 amino acids of human ABCE1
技术规格
| Full name: | ATP-binding cassette, sub-family E (OABP), member 1 |
| Synonyms: | RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI |
| Swissprot: | P61221 |
| Gene Accession: | BC016283 |
| Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | Escherichia coli |
| Tags: | His tag C-Terminus, GST tag N-Terminus |
| Background: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. |
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