| 溶解性 | DMSO 100 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A cell-permeable compound that inhibits kinase activity of ATM / ATR (RETRACTED). |
| 产品介绍 | CGK 733是一种有效的ATM/ATR选择性抑制剂，IC50约为200 nM。 |
| 备注 | CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM. |
| 生化机理 | ATM/ATR Kinase Inhibitor (CGK733) Was originially published as a cell permeable compound that selectively inhibits the kinase activity of ATM and ATR at an IC50 ~ 200 nM without significant effect against other PIKK family members DNA-PK, mTOR and PI 3-kinase (PI3K) or kinases that are known to phosphorylate p53 (ERK, Cytokeratin 1(CAK), Cdk2, JNK, PKC, cyclin H(CAK), Chk1, PKR, and p38). The claims of this product we retracted and the effect of the ATM/ATR Kinase Inhibitor (CGK733) have not been fully investigated |
| 别名 | alpha-苯基-N-[2,2,2-三氯-1-[[[(4-氟-3-硝基苯基)氨基]硫代甲酰]氨基]乙基]-苯乙酰胺CGK-733;ATM/ATR Kinase Inhibitor;alpha-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide |
CGK 733,ATR和ATM激酶抑制剂
CGK 733 （订货以英文为准）
编号：C129735
CAS号：905973-89-9
分子式：C23H18CL3FN4O3S
分子量：555.84
| 产品名称 | CGK 733 |
| 中文名称 | CGK 733,ATR和ATM激酶抑制剂 |
| CAS号 | 905973-89-9 |
| 分子式（M.F.） | C23H18CL3FN4O3S |
| 分子量（M.W.） | 555.84 |
| 储存条件 | 2-8°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Warning |
| 危害声明 | H315-H319-H335 |
| 警示性声明 | P261-P305 + P351 + P338 |
| 个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
| WGK德国 | 3 |
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