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双吲哚马来酰亚胺I

GF109203X （订货以英文为准）

编号：G129390
CAS号：133052-90-1
分子式：C25H24N4O2
分子量：412.48
货号 品牌 包装 目录价 您的价格 库存 数量 购买
G129390-10mg 阿拉丁 10mg ¥646.90
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G129390-50mg 阿拉丁 50mg ¥2040.90
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G129390-1mg 阿拉丁 1mg ¥277.90
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G129390-5mg 阿拉丁 5mg ¥411.90
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产品名称 GF109203X
中文名称 双吲哚马来酰亚胺I
CAS号 133052-90-1
MDL编码 MFCD00236428
分子式（M.F.） C25H24N4O2
分子量（M.W.） 412.48
储存条件 2-8°C储存
溶解性Soluble in DMSO (~1 mg/ml), DMF (10 mg/ml; warm to 40°C & vortex well), and 1:10 DMSO:PBS (pH 7.2) (~0.1 mg/ml). Insoluble in water.
存贮条件储存温度2-8℃
应用A highly selective inhibitor of all PKC isoforms and slight inhibitor of GSK-3
产品介绍GF109203X是一种有效的PKC抑制剂，抑制PKCα， PKCβI， PKCβII和PKCγ，IC50分别为20 nM， 17 nM， 16nM和20 nM，作用于PKC比作用于EGFR， PDGFR和胰岛素受体选择性高3000倍以上。
备注GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
生化机理Bisindolylmaleimide I (GF 109203X) is a staurosporine inspired molecule, which has been shown to display equally potent inhibition, but with vastly superior selectivity, for all of the known isoforms of PKC (IC50 = 8-20 nM). Inhibition is competitive with respect to ATP, which suggests that Bisindolylmaleimide I occupies the ATP binding domain of the PKC isoforms. Bisindolylmaleimide I (GF 109203X) has been used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals. It inhibits PKC within intact platelets and T cells, Fas-mediated apoptosis, and T cell-mediated autoimmune diseases, as well as GSK-3.
别名3-[1-[3-(二甲氨基)丙基]1H-吲哚-3-基]-4-(吲哚-3-基)1H-吡咯-2,5二酮;;双吲哚马来酰亚胺 I;Bisindolylmaleimide I;3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-Pyrrole-2,5-dione,
标识符号https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词Warning
危害声明H302
个人防护设备dust mask type N95 (US), Eyeshields, Gloves
WGK德国3
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