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AM630,CB2 大麻素拮抗剂/反向激动剂

AM630 （订货以英文为准）

编号：A124994
CAS号：164178-33-0
分子式：C23H25IN2O3
分子量：504.36
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A124994-25mg 阿拉丁 25mg ¥2176.90
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A124994-5mg 阿拉丁 5mg ¥493.90
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A124994-100mg 阿拉丁 100mg ¥5560.90
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产品名称 AM630
中文名称 AM630,CB2 大麻素拮抗剂/反向激动剂
CAS号 164178-33-0
MDL编码 MFCD01861183
分子式（M.F.） C23H25IN2O3
分子量（M.W.） 504.36
储存条件 2-8°C储存
沸点605.93 °C at 760 mmHg
折光率1.65
溶解性Soluble in DMSO, DMF, ethanol, water (0.2 mg/ml) at 25 °C, and 1:4 DMF:PBS(pH 7.2) (0.2 mg/ml).
存贮条件储存温度2-8℃
密度1.5000
应用A selective CB2 receptor antagonist that binds to CB1 and CB2 receptors
产品介绍AM630是CB2拮抗剂，Ki为31.2 nM，比对CB1受体的抑制性高150倍以上。
生化机理AM630 is a selectivity CB2 antagonist with Ki of 31.2 nM; > 150 fold selectivity over CB1 receptor.AM630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 uM and 31.2 nM, respectively. AM630 has been shown to display 165-fold selectivity over CB1 receptors and behave as a weak partial/inverse agonist at CB1 receptors. AM630 acts as a cannabinoid receptor antagonist in mouse brain, vas deferens and guinea pig brain, but acts as an agonist in guinea pig leum. AM630 acts as an inverse agonist on cloned human CB1 receptors.
别名AM 630;AM-630; [6-碘-2-甲基-1-[2-(4-吗啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮;AM 630;AM-630; 6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone; Iodopravadoline
Reaxys-RN4552782
标识符号https://www.aladdin-e.com/images/ghs/ghs06.jpg
信号词Danger
危害声明H301
警示性声明P301 + P310
WGK德国3
搜索质检报告(COA)
搜索MSDS
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