| 溶解性 | DMSO 74 mg/mL Water <1 mg/mL Ethanol 74 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM. It is less potent to CDK5/6 and also inhibits GSK3β. Phase 1. |
| 生化机理 | AZD-5438 is a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). AZD-5438 exhibits antiproliferative activity in human tumor cell lines. AZD-5438 blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo. |
| 别名 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine;4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine |
AZD5438,细胞周期蛋白依赖性激酶的抑制剂
AZD5438 （订货以英文为准）
编号：A126894
CAS号：602306-29-6
分子式：C18H21N5O2S
分子量：371.46
| 产品名称 | AZD5438 |
| 中文名称 | AZD5438,细胞周期蛋白依赖性激酶的抑制剂 |
| CAS号 | 602306-29-6 |
| 分子式（M.F.） | C18H21N5O2S |
| 分子量（M.W.） | 371.46 |
| 储存条件 | -20°C储存 |
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