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LCL161，抑制剂

LCL161 （订货以英文为准）

编号：L127178
CAS号：1005342-46-0
分子式：C26H33FN4O3S
分子量：500.63
货号 品牌 包装 目录价 您的价格 库存 数量 购买
L127178-10mg 阿拉丁 10mg ¥897.90
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L127178-5mg 阿拉丁 5mg ¥526.90
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L127178-50mg 阿拉丁 50mg ¥2998.90
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产品名称 LCL161
中文名称 LCL161，抑制剂
CAS号 1005342-46-0
分子式（M.F.） C26H33FN4O3S
分子量（M.W.） 500.63
储存条件 -20°C储存
溶解性25°C: DMSO
存贮条件储存温度-20°C
产品介绍LCL161，一个SMAC模拟的，能有效地结合并抑制多元IAPs(i.e. XIAP, c-IAP)。Phase 2。
生化机理Description:IC50 Value: N/ALCL161 is an oral small molecule antagonist of Inhibitor of Apoptosis Proteins (IAPs) that sensitizes a subset of tumors from diverse lineages to treatment with cytotoxic therapies.in vitro: Huh-7 cells co-treated with LCL161 and SC-2001 showed a significant dose-dependent apoptotic effect demonstrated by sub-G1 assay and cleavage of PARP. Furthermore, the combination index (CI) ofLCL161 and SC-2001 showed a convincing synergism in resistant Huh-7 [1]. Results in human liver microsomes indicated LCL161 inhibited CYP3A in a concentration- and time-dependent manner (KI of 0.797??M and kinact of 0.0803?min(-1) ). LCL161 activated human PXR in a reporter gene assay and induced CYP3A4 mRNA up to ?5-fold in human hepatocytes [2]. LCL161 caused rapid degradation of cIAP1 leading to TNFα secretion, LCL161 did not promote apoptosis significantly. However, LCL161 induced expression of MICA and MICB, ligands for the activating im
别名;LCL-161;LCL 161;(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-propanamide;N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-(2S)-propanamide
标识符号https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词Warning
危害声明H315-H319-H335
警示性声明P261-P305 + P351 + P338
个人防护设备dust mask type N95 (US), Eyeshields, Gloves
WGK德国3
搜索质检报告(COA)
搜索MSDS
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