| 溶解性 | DMSO 100 mg/ml |
| 存贮条件 | 储存温度2-8℃ |
| 产品介绍 | IOX2是低氧诱导因子（HIF）脯氨酰羟化酶（PHD）抑制剂，在细胞中对PHD2/ELGN-1的IC50为21 nM，对FIH无活性。 |
| 备注 | IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. |
| 生化机理 | IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish. |
| 别名 | IOX 2;IOX-2;JICL38;N-((4-羟基-2-氧代-1-(苯基甲基)-1,2-二氢-3-喹啉基)羰基)甘氨酸;;IOX 2;IOX-2;JICL38; N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine; N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine |
IOX2,脯氨酰羟化酶2（PHD2）抑制剂
IOX2 （订货以英文为准）
编号：I127127
CAS号：931398-72-0
分子式：C19H16N2O5
分子量：352.34
| 产品名称 | IOX2 |
| 中文名称 | IOX2,脯氨酰羟化酶2（PHD2）抑制剂 |
| CAS号 | 931398-72-0 |
| 分子式（M.F.） | C19H16N2O5 |
| 分子量（M.W.） | 352.34 |
| 储存条件 | 2-8°C储存 |
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