沸点 | 167°C |
熔点 | 83-84°C |
敏感性 | 易吸潮,对热和光敏感 |
溶解性 | Soluble in water, alcohol, and hot chloroform. |
存贮条件 | 储存温度-20°C |
密度 | 1.1400 |
应用 | 内源性H1 和 H2 组胺受体激动剂;H1 激活并使Ca2+移动;H2 激活并刺激神经元中腺苷酸环化酶(adenylate cyclase)活性;激活NO合成酶;血管扩张剂。 |
产品介绍 | 有吸湿性。在日光下易变质。组胺由组氨酸脱羧基形成,广泛分布在哺乳动物的组织中,尤其在肥大细胞及有关嗜碱性白细胞内(在变态反应中肥大细胞释放出组胺)。可以组氨酚为原料发酵制得。 |
生化机理 | Histamine, Free Base is a potent vasodilator found in normal tissues and blood. This compound is formed by the decarboxylation of L-histidine and activates NOS (nitric oxide synthase), resulting in the release of nitric oxide. Activation of Histamine H1 Receptors leads to Ca2+ mobilization; whereas, Histamine H2 Receptor activation stimulates adenylate cyclase activity in neurons. Histamine inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation. |
别名 | β-氨乙基咪唑;1H-咪唑-4-乙胺;2-(4-咪唑基)乙胺;2-(4-Imidazolyl)ethylamine;1H-Imidazole-4-ethanamine; Ergotidine |
组胺
Histamine, Free Base (订货以英文为准)
编号:H111796
CAS号:51-45-6
产品名称 | Histamine, Free Base |
中文名称 | 组胺 |
CAS号 | 51-45-6 |
储存条件 | 避光;-20°C储存;充氩 |
标识符号 | https://www.aladdin-e.com/images/ghs/ghs06.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
信号词 | Danger |
危害声明 | H301,H315,H317,H319,H334,H335 |
警示性声明 | P261,P280,P301+P310,P305+P351+P338,P342+P311 |
个人防护设备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
RTECS | MS1050000 |
WGK德国 | 3 |
风险声明 (欧洲) | 22,36/37/38,42/43 |
安全声明(欧洲) | 22,26,36/37 |
危害码(欧洲) | Xn |
UN代码 | 2811 |
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