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AT13387,Hsp90抑制剂

AT13387 （订货以英文为准）

编号：A127900
CAS号：912999-49-6
分子式：C24H31N3O3
分子量：409.52
货号 品牌 包装 目录价 您的价格 库存 数量 购买
A127900-10mg 阿拉丁 10mg ¥394.90
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A127900-50mg 阿拉丁 50mg ¥1384.90
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A127900-5mg 阿拉丁 5mg ¥244.90
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A127900-250mg 阿拉丁 250mg ¥4999.90
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A127900-100mg 阿拉丁 100mg ¥2212.90
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产品名称 AT13387
中文名称 AT13387,Hsp90抑制剂
CAS号 912999-49-6
分子式（M.F.） C24H31N3O3
分子量（M.W.） 409.52
储存条件 -20°C储存
溶解性DMSO 25 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
备注AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity.
生化机理AT13387 is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor AT13387 selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins. AT13387 is a selective potent heat shock protein 90 (Hsp90) inhibitor with IC50 of 18 nM in A375 cells. The Kd for AT13387 binding is 0.7 nM.
别名(2,4-dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone;(2,4-dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone
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