溶解性 | DMSO 86 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
存贮条件 | 储存温度-20°C |
产品介绍 | AZD5363是各种AKT亚型抑制剂,IC50<10nM。 |
生化机理 | AZD5363, a novel pyrrolopyrimidine-derived compound, inhibited all AKT isoforms with a potency of 10 nmol/L or less and inhibited phosphorylation of AKT substrates in cells with a potency of approximately 0.3 to 0.8 μmol/L. AZD5363 monotherapy inhibited the proliferation of 41 of 182 solid and hematologic tumor cell lines with a potency of 3 μmol/L or less。 |
别名 | AZD-5363;AZD 5363;4-氨基-N-((1S)-1-(4-氯苯基)-3-羟基丙基)-1-(7H-吡咯并(2,3-d)嘧啶-4-基)-4-哌啶甲酰胺;;AZD-5363;AZD 5363; 4-amino-n-((1s)-1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-4-piperidinecarboxamide |
AZD5363,泛泛AKT抑制剂
AZD5363 (订货以英文为准)
编号:A128036
CAS号:1143532-39-1
分子式:C21H25CLN6O2
分子量:428.92
产品名称 | AZD5363 |
中文名称 | AZD5363,泛泛AKT抑制剂 |
CAS号 | 1143532-39-1 |
分子式(M.F.) | C21H25CLN6O2 |
分子量(M.W.) | 428.92 |
储存条件 | -20°C储存 |
搜索质检报告(COA)
搜索MSDS
相关产品