AZD5363,泛泛AKT抑制剂

AZD5363 (订货以英文为准)

编号:A128036
CAS号:1143532-39-1
分子式:C21H25CLN6O2
分子量:428.92
货号 品牌 包装 目录价 您的价格 库存 数量 购买
A128036-100mg 阿拉丁 100mg ¥1658.90
A128036-5mg 阿拉丁 5mg ¥388.90
A128036-25mg 阿拉丁 25mg ¥647.90
A128036-50mg 阿拉丁 50mg ¥1036.90
产品名称 AZD5363
中文名称 AZD5363,泛泛AKT抑制剂
CAS号 1143532-39-1
分子式(M.F.) C21H25CLN6O2
分子量(M.W.) 428.92
储存条件 -20°C储存
溶解性DMSO 86 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
产品介绍AZD5363是各种AKT亚型抑制剂,IC50<10nM。
生化机理AZD5363, a novel pyrrolopyrimidine-derived compound, inhibited all AKT isoforms with a potency of 10 nmol/L or less and inhibited phosphorylation of AKT substrates in cells with a potency of approximately 0.3 to 0.8 μmol/L. AZD5363 monotherapy inhibited the proliferation of 41 of 182 solid and hematologic tumor cell lines with a potency of 3 μmol/L or less。
别名AZD-5363;AZD 5363;4-氨基-N-((1S)-1-(4-氯苯基)-3-羟基丙基)-1-(7H-吡咯并(2,3-d)嘧啶-4-基)-4-哌啶甲酰胺;;AZD-5363;AZD 5363; 4-amino-n-((1s)-1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-4-piperidinecarboxamide
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