| 溶解性 | DMSO 64 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | 一种新型HDAC抑制剂 |
| 产品介绍 | Belinostat (PXD101)是一种新型的HDAC抑制剂，IC50为27 nM，对抵抗Cisplatin的肿瘤有效。 |
| 备注 | Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM, with activity demonstrated in cisplatin-resistant tumors. Phase 1/2. |
| 生化机理 | Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM. Belinostat inhibits the growth of tumor cells (A2780, HCT116, HT29, WIL, CALU-3, MCF7, PC3 and HS852) with IC50 from 0.2-0.66 μM. PD101 shows low activity in A2780/cp70 and 2780AD cells. Belinostat inhibits bladder cancer cell growth, especially in 5637 cells, which shows accumulation of G0-G1 phase, decrease in S phase, and increase in G2-M phase. Belinostat also shows enhanced tubulin acetylation in ovarian cancer cell lines. A recent study shows that Belinostat activates protein kinase A in a TGF-β signaling-dependent mechanism and decreases survivin mRNA. |
| 别名 | N-羟基-3-(3-苯基氨基磺酰基苯基)丙烯酰胺;PXD101;PX105684;PXD-101;PXD 101;PX-105684;N-Hydroxy-3-(3-phenylsulfamoylphenyl)acrylamide;(2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]acrylamide |
贝利司他 (PXD101)
Belinostat (PXD101) （订货以英文为准）
编号：B126780
CAS号：414864-00-9
分子式：C15H14N2O4S
分子量：318.35
| 产品名称 | Belinostat (PXD101) |
| 中文名称 | 贝利司他 (PXD101) |
| CAS号 | 414864-00-9 |
| 分子式（M.F.） | C15H14N2O4S |
| 分子量（M.W.） | 318.35 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs09.jpg |
| 信号词 | Warning |
| 危害声明 | H302,H400 |
| 警示性声明 | P273 |
| WGK德国 | 3 |
| 风险声明 (欧洲) | R22;R50/53 |
| 安全声明（欧洲） | S60;S61 |
| 危害码（欧洲） | Xn,N |
搜索质检报告(COA)
搜索MSDS
相关产品
党沛 
