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FK866 (APO866, Daporinad),NAMPT抑制剂

FK866 (APO866, Daporinad) （订货以英文为准）

编号：F127321
CAS号：658084-64-1
分子式：C24H29N3O2
分子量：391.51
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F127321-100mg 阿拉丁 100mg ¥5767.90
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F127321-25mg 阿拉丁 25mg ¥2059.90
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F127321-5mg 阿拉丁 5mg ¥529.90
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产品名称 FK866 (APO866, Daporinad)
中文名称 FK866 (APO866, Daporinad),NAMPT抑制剂
CAS号 658084-64-1
分子式（M.F.） C24H29N3O2
分子量（M.W.） 391.51
储存条件 -20°C储存
敏感性易吸湿
溶解性Soluble in ethanol (78 mg/ml at 25 °C), DMF (40 mg/ml), DMSO (100 mg/ml), PBS (pH 7.2) (~0.5 mg/ml), and water (<1 mg/ml at 25 °C), DMSO 25mg/ml Ethanol dimethyl formamide
存贮条件储存温度-20°C
应用A highly specific non-competitive inhibitor of NAMPT
产品介绍FK866 (APO866, Daporinad)有效抑制烟酰胺磷酸核糖转移酶(NMPRTase)，无细胞试验中IC50为0.09 nM。Phase 1/2。
备注APO866 effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM. Phase 1/2.
生化机理FK-866 has been shown to induce apoptosis by non-competitive, and specific inhibition of nicotamide phosphoribosyltransferase (NAMPT). NAMPT is a key regulatory enzyme that mediates NAD+ biosynthesis within cells. Mechanistic studies show that this compound contains an enzymatic active site of visfatin which is optimized for nicotinamide binding and inhibition. Visfatin also contains a similar structure to insulin and mimics its actions by binding to the insulin receptors.
别名(2E)-N-[4-(1-苯甲酰基-4-哌啶基)丁基]-3-(3-吡啶基)-2-丙烯酰胺;Daporinad; APO866; FK-866; FK 866; APO 866; APO-866;(E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide
标识符号https://www.aladdin-e.com/images/ghs/ghs06.jpg
信号词Danger
危害声明H301
警示性声明P301 + P310
WGK德国3
搜索质检报告(COA)
搜索MSDS
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