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NBD-557,HIV-1抑制剂

NBD-557 （订货以英文为准）

编号：N125473
CAS号：333352-59-3
分子式：382.3
货号 品牌 包装 目录价 您的价格 库存 数量 购买
N125473-25mg 阿拉丁 25mg ¥3604.90
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N125473-5mg 阿拉丁 5mg ¥967.90
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N125473-50mg 阿拉丁 50mg ¥5149.90
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产品名称 NBD-557
中文名称 NBD-557,HIV-1抑制剂
CAS号 333352-59-3
分子式（M.F.） 382.3
储存条件 -20°C储存
溶解性DMSO
存贮条件储存温度-20°C
产品介绍NBD-557是HIV-1抑制剂。
生化机理NBD-557, is small molecule organic compounds with drug-like properties. It showed potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels. A systematic study showed that NBD-557 target viral entry by inhibiting the binding of HIV-1 envelope glycoprotein gp120 to the cellular receptor CD4 but did not inhibit reverse transcriptase, integrase, or protease, indicating that they do not target the later stages of the HIV-1 life cycle to inhibit HIV-1 infection. NBD-557 potent inhibitors of both X4 and R5 viruses tested in CXCR4 and CCR5 expressing cell lines, respectively, indicating that its anti-HIV-1 activity is not dependent on the coreceptor tropism of the virus.
别名NBD 557;NBD557;N-(4-溴苯基)-N'-(2,2,6,6-四甲基哌啶-4-基)草酰胺;NBD 557;NBD557;N-(4-Bromophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide;N1-(4-bromophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)ethanediamide
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