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Daclatasvir (BMS-790052)

Daclatasvir (BMS-790052) （订货以英文为准）

编号：D127186
CAS号：1009119-64-5
分子式：C40H50N8O6
分子量：738.88
货号 品牌 包装 目录价 您的价格 库存 数量 购买
D127186-50mg 阿拉丁 50mg ¥129.90
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D127186-10mg 阿拉丁 10mg ¥64.90
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D127186-250mg 阿拉丁 250mg ¥369.90
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D127186-1g 阿拉丁 1g ¥988.90
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D127186-100mg 阿拉丁 100mg ¥213.90
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产品名称 Daclatasvir (BMS-790052)
中文名称 Daclatasvir (BMS-790052)
CAS号 1009119-64-5
分子式（M.F.） C40H50N8O6
分子量（M.W.） 738.88
储存条件 -20°C储存
溶解性DMSO 148 mg/mL Water <1 mg/mL Ethanol 148 mg/mL
存贮条件储存温度-20°C
产品介绍Daclatasvir (BMS-790052)是一种高度选择性的HCV NS5A抑制剂，EC50为9-50 pM，在细胞培养中，作用于多种HCV复制基因型和JFH-1基因型2a的感染性病毒。
备注BMS-790052 is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. Phase 3.
生化机理Daclatasvir (BMS-790052; EBP 883) is a first-in-class, highly-selective oral HCV NS5A inhibitor. NS5A is an essential component for hepatitis C virus (HCV) replication complex.Daclatasvir (BMS-790052; EBP 883)has broad genotype coverage and exhibits picomolar in vitro potency against genotypes 1a (EC50 50pm) and 1b (EC50 9pm).Daclatasvir (BMS-790052; EBP 883) produces a robust decline in HCV RNA (-3.6 logs after 48 hours from a single 100 mg) dosefollowing a single dose in patients chronically infected with HCV genotype 1.
别名达卡他韦; N,N'-[[1,1'-联苯]-4,4'-二基双[1H-咪唑-5,2-二基-(2S)-2,1-吡咯烷二基 [(1S)-1-(1-甲基乙基)-2-氧代-2,1-乙烷二基]]]双氨基甲酸 C,C'-二甲酯;BMS-790052; EBP 883; BMS 790052; N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid C,C'-dimethyl ester
标识符号https://www.aladdin-e.com/images/ghs/ghs08.jpg
信号词Warning
危害声明H361fd
警示性声明P281
个人防护设备Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSDG2736000
WGK德国nwg
搜索质检报告(COA)
搜索MSDS
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