1. 首页
  2. 产品目录

PF-5274857

PF-5274857 （订货以英文为准）

编号：P126554
CAS号：1373615-35-0
分子式：C20H25CLN4O3S
分子量：436.96
货号 品牌 包装 目录价 您的价格 库存 数量 购买
P126554-50mg 阿拉丁 50mg ¥1721.90
请登录
P126554-5mg 阿拉丁 5mg ¥283.90
请登录
P126554-10mg 阿拉丁 10mg ¥454.90
请登录
P126554-1mg 阿拉丁 1mg ¥87.90
请登录
P126554-25mg 阿拉丁 25mg ¥967.90
请登录
P126554-100mg 阿拉丁 100mg ¥2752.90
请登录
产品名称 PF-5274857
中文名称 PF-5274857
CAS号 1373615-35-0
分子式（M.F.） C20H25CLN4O3S
分子量（M.W.） 436.96
储存条件 -20°C储存
溶解性DMSO 93 mg/mL Water 93 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
备注PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
生化机理PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells. This Smo antagonist PF-5274857 showed robust antitumor activity in a mouse model of medulloblastoma with an in vivo IC(50) of 8.9 ± 2.6 nmol/L. PF-5274857 was orally available and metabolically stable in vivo. PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hedgehog (Hh) signaling pathway.
别名1-(4-(5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one;1-(4-(5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one
标识符号https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词Warning
危害声明H315,H319,H335
警示性声明P261,P305+P351+P338
WGK德国3
风险声明 (欧洲)36/37/38
安全声明（欧洲）26
危害码（欧洲）Xi
搜索质检报告(COA)
搜索MSDS
相关产品